Publications

Divergent Synthesis of Pyrrolizine- and Indolizine-Fused Heterocycles via Pd(II)-Catalyzed CascadeTransformation of Functionalized Alkynes

Tanvi Jandial, Anish Gupta, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2025, 90, 11923–11939

One-Pot, Two-Step Synthesis of Highly Functionalized 4-Indolyl/Pyrrolyl-Chromanes via a para-Quinone Methide Formation–1,8-Addition Sequence

Rafia Khatoon, Tanvi Jandial, Anish Gupta, Sujata Kundan, Vellaisamy Sridharan*

Synthesis, 2025, 25, 218-228

(Special Topic Dedicated to Prof. H. Ila)

Microwave-Assisted Selective Nucleopalladation-Triggered Cascade Process: Synthesis of Highly Functionalized 3-Chloro-1H-indenes

Tanvi Jandial, Anish Gupta, Dolma Tsering, Kamal K. Kapoor, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2024, 89, 12989–13004

Revealing the Role of Solvent in anti-Oxypalladation-Triggered Regiocontrolled Domino Reactions for the Synthesis of Benzazepine- and Tetrahydroquinoline-Containing Scaffolds: A Combined Computational and Experimental Study

Anish Gupta, Sheetal Ranaut, Athira Kooleri, Tanvi Jandial, Neha Rani, Nattamai Bhuvanesh, Shivnath Mazumder*, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2024, 89, 13038–13058

FeCl3-Catalyzed AB2 Three-Component [3+3] Annulation: An Efficient Access to Functionalized Indolo[3,2-b]carbazoles

Gowsia Jan, Diksha Rajput, Anish Gupta, Dolma Tsering, Muthu Karuppasamy, Kamal K. Kapoor, Vellaisamy Sridharan*

Organic Chemistry Frontiers, 2023, 10, 5978–5985

Palladium-Catalyzed Intramolecular Oxypalladation-Initiated Cascade: Solvent-Dependent Chemodivergent Approach to Functionalized Benzazepines and Tetrahydroquinolines

Anish Gupta, Tanvi Jandial, Muthu Karuppasamy, Nattamai Bhuvanesh, Subbiah Nagarajan, C. Uma Maheswari, Vellaisamy Sridharan*

Chemical Communications, 2023, 59, 5233–5236

Diversity-Oriented Synthesis of Benzo[f][1,4]oxazepine-, 2H-Chromene- and 1,2-Dihydroquinoline-Fused Polycyclic Nitrogen Heterocycles under Microwave-Assisted Conditions

Diksha Rajput, Dolma Tsering, Muthu Karuppasamy, Kamal K. Kapoor, Subbiah Nagarajan, C. Uma Maheswari, Nattamai Bhuvanesh, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2023, 88, 8643–8657

Rapid Assembly of Functionalized 2H‑Chromenes and 1,2- Dihydroquinolines via Microwave-Assisted Secondary Amine-Catalyzed Cascade Annulation of 2‑O/N‑Propargylarylaldehydes with 2,6-Dialkylphenols

Diksha Rajput, Gowsia Jan, Muthu Karuppasamy, Nattamai Bhuvanesh, Subbiah Nagarajan, C. Uma Maheswari, J. Carlos Menéndez, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2023, 88, 11778–11792

A Microwave-Assisted Intramolecular Aminopalladation-Triggered Domino Sequence: An Atom Economical Route to 5,10-Dihydroindeno[1,2-b]indoles

Tanvi Jandial, Anish Gupta, Gowsia Jan, Muthu Karuppasamy, Subbiah Nagarajan, C. Uma Maheswari and Vellaisamy Sridharan*

Organic and Biomolecular Chemistry, 2023, 21, 3121–3131

Intramolecular Oxypalladation-Initiated Domino Sequence: One-pot, Two-step Regioselective Synthesis of Isoquinolines

Perumal Vinoth, Muthu Karuppasamy, Anish Gupta, Subbiah Nagarajan, C. Uma Maheswari, Vellaisamy Sridharan*

Tetrahedron, 2023,134, 133272

Iodine-Catalyzed Three-Component Annulation: Access to Highly Fluorescent Trisubstituted Thiophenes

Deepan Babu Rajkumar, Karthiyayini Gnanaoli, Arulmozhi Puhazhendhi, Tamilselvi Arunachalam, Subbiah Nagarajan, Vellaisamy Sridharan, Soumya Sivalingam, C. Uma Maheswari*

Chemical Communications, 2023, 59, 10129–10132

Microwave-Assisted One-pot Two-step Imine Formation–Hetero-Diels-Alder–Detosylation/Aromatization Sequence: Direct Access to Dibenzo[b,h][1,6]naphthyridines

Gowsia Jan, Atul Kumar, Muthu Karuppasamy, Diksha Rajput, Nancy Slathia, Kamal K. Kapoor,
Vellaisamy Sridharan*

Organic and Biomolecular Chemistry, 2022, 20, 7472–7482

Microwave-Assisted Copper(II)-Catalyzed Cascade Cyclization of Alkynes: Access to Densely Functionalized Imidazo[1,2-d][1,4]oxazepines and Imidazo[1,2-d][1,4]diazepines

Diksha Rajput, Atul Kumar, Tanvi Jandial, Muthu Karuppasamy, Nattamai Bhuvanesh, R. Suresh Kumar, A. I. Almansour, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2022, 87, 8956–8969

Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions

Victor González-Ruiz, Angel Cores, M. Mar Caja, Vellaisamy Sridharan, Mercedes Villacampa, M. Antonia Martín, Ana I. Olives,* J. Carlos Menéndez*

Biosensors, 2022, 12, 175

Synthesis of Fused Quinoline Derivatives from Easily Accessible N-(2-Aminobenzylidene)-4-Methylanilines under Catalyst-Free Conditions in Water

Thavaraj Vivekanand, Atul Kumar, J. Carlos Menéndez, R. Suresh Kumar, A. I. Almansour, Natarajan Arumugam, Vellaisamy Sridharan*

ChemistrySelect, 2021, 6, 10436–10439

Direct Access to Bridged Tetrahydroquinolines and Chromanes via An InCl3-Catalyzed Sequential Three-Component Cascade

B. S. Vachan, Muthu Karuppasamy, Gowsia Jan, Nattamai Bhuvanesh, C. Uma Maheswari*, Vellaisamy Sridharan*

The Journal of Organic Chemistry, 2020, 85, 8062–8073

Palladium(II)-Catalyzed Direct Access to Indeno[1,2-c]isochromen-5(11H)-ones via Intramolecular Oxypalladation-Initiated Cascade Process

Muthu Karuppasamy, B. S. Vachan, Tanvi Jandial, Sesuraj Babiola Annes, N. Bhuvanesh, C. U. Maheswari, Vellaisamy Sridharan*

Advanced Synthesis & Catalysis, 2020, 362, 2716–2724

Chemodivergent Synthesis of Functionalized Methanodibenzo[b,f][1,5]diazocin-13-ylmethanones and Tetrahydroquinolines via Solvent-Dependent AB2 and A2B2 Multicomponent Annulation Reactions

Isravel Muthukrishnan, Muthu Karuppasamy, B. S. Vachan, Diksha Rajput, Subbiah Nagarajan, C. Uma Maheswari, Vellaisamy Sridharan*

Organic Chemistry Frontiers, 2020, 7, 1616–1625

Proline and Its Derivatives as Organocatalysts for Multicomponent Reactions in Aqueous Media: Synergic Pathways to the Green Synthesis of Heterocycles

B. S. Vachan, Muthu Karuppasamy, Perumal Vinoth, Sundaravel Vivek Kumar, Subbu Perumal, Vellaisamy Sridharan,* J. Carlos Menéndez*

Advanced Synthesis & Catalysis, 2020, 362, 87–110

N-Heterocyclic Carbene Catalyzed Synthesis of Trisubstituted Epoxides via Tandem Amidation/Epoxidation Sequence

E. Sankari Devi, Thangavel Pavithra, A. Tamilselvi, Subbiah Nagarajan, Vellaisamy Sridharan, C. Uma Maheswari*

Organic Letters, 2020, 22, 3576–3580

Regioselective Synthesis of Tetrahydroquinolines via Syn- and Anti-Nucleopalladation-Initiated Cascade Processes

Muthu Karuppasamy, Perumal Vinoth, N. Pradeep, Subbiah Nagarajan, C. Uma Maheswari, Vellaisamy Sridharan*

Organic and Biomolecular Chemistry, 2020, 18, 8474–8485

A Novel Indenone Derivative Selectively Induces Senescence in MDA-MB-231 (breast adenocarcinoma) Cells

J. Priyanga, B. Sharan Kumar, R. Mahalakshmi, K. Nirekshana, P. Vinoth, Vellaisamy Sridharan, Dipita Bhakta-Guha*, Gunjan Guha*

Chemico-Biological Interactions, 2020, 331, 109250

Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants

Victor González-Ruiz, J. Rajesh, Ana I. Olives, Damiano Rocchi, J. Gómez-Carpintero, Juan F. González, Vellaisamy Sridharan, M. Antonia Martín,* J. Carlos Menéndez*

Antioxidants, 2020, 9, 605

Highly Chemoselective Difluoromethylative Homologation of Iso(thio)cyanates: Expeditious Access to Unprecedented α,α-Difluoro(thio)amides

Margherita Miele, Rosarita D’Orsi, Vellaisamy Sridharan, Wolfgang Holzer and Vittorio Pace*

Chemical Communications 2019, 55, 12960–12963

Direct Access to 9-Chloro-1H-Benzo[b]furo[3,4-e]azepin-1-ones via Palladium(II)-Catalyzed Intramolecular syn-Oxypalladation-Olefin Insertion-sp2C–H Bond Activation Cascade

Muthu Karuppasamy, B. S. Vachan, Perumal Vinoth, Isravel Muthukrishnan, Subbiah Nagarajan, Laura Ielo, Vittorio Pace, Subrata Banik, C. Uma Maheswari, Vellaisamy Sridharan*

Organic Letters 2019, 21, 5784–5788

Palladium-Catalyzed Regioselective syn-Chloropalladation-Olefin Insertion-Oxidative Chlorination Cascade: Synthesis of Dichlorinated Tetrahydroquinolines

Perumal Vinoth, Muthu Karuppasamy, B. S. Vachan, Isravel Muthukrishnan, C. Uma Maheswari, Subbiah Nagarajan, Vittorio Pace, Alexander Roller, Nattamai Bhuvanesh, Vellaisamy Sridharan*

Organic Letters 2019, 21, 3465–3469

Heterogeneous Amberlyst-15-Catalyzed Synthesis of Complex Hybrid Heterocycles Containing [1,6]-Naphthyridine Under Metal-Free Green Conditions

Isravel Muthukrishnan, B. S. Vachan, Muthu Karuppasamy, A. Eniyaval, C. Uma Maheswari, Subbiah Nagarajan, J. Carlos Menéndez, Vellaisamy Sridharan*

Organic and Biomolecular Chemistry 2019, 17, 6872–6879

Diastereoselective ABB′ Three-Component Synthesis of Highly Functionalized Spirooxindoles Bearing Five Consecutive Asymmetric Carbons

Thavaraj Vivekanand, B. S. Vachan, Muthu Karuppasamy, Isravel Muthukrishnan, C. Uma Maheswari, Subbiah Nagarajan, Nattamai Bhuvanesh, Vellaisamy Sridharan*

The Journal of Organic Chemistry 2019, 84, 4009–4016

Progress in the Chemistry of Tetrahydroquinolines

Isravel Muthukrishnan, Vellaisamy Sridharan,* J. Carlos Menéndez*

Chemical Reviews 2019, 119, 5057–5191

Oxidant-free, Three-Component Synthesis of 7-Amino-6H-benzo[c]chromen-6-ones under Green Conditions

B. S. Vachan, Aishwarya Ramesh, Muthu Karuppasamy, Isravel Muthukrishnan, Subbiah Nagarajan, J. Carlos Menéndez, C. Uma Maheswari* Vellaisamy Sridharan*

RSC Advances 2019, 9, 32946–32953

Synthesis, Characterization and Biomedical Applications of an Alkylated Quercetin-Gadolinium Complex

Sathyasivam Kaviarasi, K. S. Shalini Devi, Perumal Vinoth, Vellaisamy Sridharan, Eiji Yuba, Atsushi Harada, U. Maheswari Krishnan*

ACS Biomaterials Science & Engineering 2019, 5, 1215–1227

Three-Component Synthesis of a Library of m-Terphenyl Derivatives with Embedded β-Aminoester Moieties

Damiano Rocchi, Juan F. González, Jorge Gómez-Carpintero, Victor González-Ruiz, M. Antonia Martín, Vellaisamy Sridharan, J. Carlos Menéndez*

ACS Combinatorial Science 2018, 20, 722–731

Exploration of Antifungal and Immunomodulatory Potentials of a Furanone Derivative to Rescue Disseminated Cryptococosis in Mice

Sudarshan S. Rathore, Muthukrishnan Isravel, Vellaisamy Sridharan, David R. Chellappan, Lalitha Cheepurupalli, Thiagarajan Raman, Jayapradha Ramakrishnan*

Scientific Reports 2017, 7, 15400

Synthesis of 6,12-Epiminodibenzo[b,f][1,5]diazocines via an Ytterbium Triflate-Catalyzed, AB2 Three-Component Reaction

Isravel Muthukrishnan, Muthu Karuppasamy, Subbiah Nagarajan, C. Uma Maheswari, Vittorio Pace, J. Carlos Menéndez, Vellaisamy Sridharan*

The Journal of Organic Chemistry 2016, 81, 9687–9694

Palladium–Catalyzed Internal Nucleophile–Assisted Hydration–Olefin Insertion Cascade: Diastereoselective Synthesis of 2,3-Dihydro-1H-inden-1-ones

Perumal Vinoth, Subbiah Nagarajan, C. Uma Maheswari, Arumugam Sudalai, Vittorio Pace, Vellaisamy Sridharan*

Organic Letters 2016, 18, 3442–3445

Three-Component Synthesis of Pyrrole-Related Nitrogen Heterocycles via a Hantzsch-type Process: Comparison Between Conventional and High-speed Vibration Milling Conditions

Verónica Estévez, Vellaisamy Sridharan, Sònia Sabaté, Mercedes Villacampa, J. Carlos Menéndez*

Asian Journal of Organic Chemistry 2016, 5, 652–662

Synthesis of 5,6-Dihydrodibenzo[b,h][1,6]naphthyridines via Copper Bromide Catalyzed Intramolecular [4 + 2] Hetero-Diels−Alder Reactions

Isravel Muthukrishnan, Perumal Vinoth, Thavaraj Vivekanand, Subbiah Nagarajan, C. Uma Maheswari, J. Carlos Menéndez, Vellaisamy Sridharan*

The Journal of Organic Chemistry 2016, 81, 1116–1124

School of Chemistry

University of Hyderabad