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The VSridharan Group

Our research encompasses various aspects of synthetic organic chemistry including

  1. Nucleopalladation-initiated cascade processes of alkynes

  2. Cascade organic transformations triggered by Lewis-acids/transition metal-catalysts

  3. Ni- and Fe-catalyzed organic transformations 

  4. Green and non-conventional organic transformations and

  5. Electro-organic synthesis

 

We aim to develop new synthetic methodologies involving cascade/domino reactions. We design various multi-functional reactants and explore their reactivity to access diverse complex compounds of biological relevance and investigate the mechanisms of those transformations.

Nucleopalladation-Initiated Cascade Processes of Alkynes
The nucleopalladation of alkynes, including inter- and intramolecular versions, generates σ-vinylpalladium intermediates. The in situ generated σ-vinylpalladium intermediates could undergo various cascade transformations including olefin insertion via Heck-type coupling, 1,2-addition to a carbonyl, nucleophilic addition to a nitrile group etc. Among the various nucleopalladation reactions, we predominately work on amino-, oxy-, carboxy- and halopalladation reactions and the subsequent cascade transformations to access to a wide range of carbo- and heterocycles by generating multiple bonds in one pot.

Cascade Organic Transformations Triggered by Lewis Acid/Transition Metal Catalysts Including Non-conventional Approaches
We work on the development Lewis acid/transition metal catalysed multi-bond forming cascade/MCR transformations for the synthesis of compounds of biological significance. Our approach involves the generation of versatile building blocks including enamines followed by the addition to electrophiles and generation of imines and addition of nucleophiles, and the successive domino reactions. We also focus on the domino reactions via activation of alkynes. Further we explore the microwave heating for organic synthesis, which is a fascinating and widely recognized non-conventional energy source for the execution of organic transformations. 

Electro-organic Synthesis
Our next interest is the development of electro-organic methods to replace difficult conventional approaches. In particular, we focus to explore cascade electro-organic transformations for the synthesis of complex molecules by generating multiple bonds in a single synthetic operation.

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